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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB3
All Species:
13.94
Human Site:
S478
Identified Species:
27.88
UniProt:
Q16875
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16875
NP_001138915.1
520
59609
S478
T
K
K
P
R
I
N
S
F
E
E
H
V
A
S
Chimpanzee
Pan troglodytes
XP_001147864
523
59913
S478
T
K
K
P
R
I
N
S
F
E
E
H
V
A
S
Rhesus Macaque
Macaca mulatta
XP_001107535
520
59589
S478
T
K
K
P
R
I
N
S
F
E
E
H
V
A
S
Dog
Lupus familis
XP_544267
559
63551
T491
L
V
S
C
R
H
G
T
A
D
A
K
K
A
P
Cat
Felis silvestris
Mouse
Mus musculus
P70265
519
59907
N477
F
T
P
L
S
S
S
N
T
I
R
R
P
R
N
Rat
Rattus norvegicus
O35552
555
63657
A478
V
E
S
A
K
Q
D
A
K
K
G
P
N
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516067
579
65588
T537
P
L
A
S
P
E
P
T
K
K
P
R
I
N
S
Chicken
Gallus gallus
Q91348
470
54386
Y429
L
K
L
T
P
V
A
Y
G
C
E
V
E
S
I
Frog
Xenopus laevis
NP_001088535
470
54750
Y429
L
K
L
T
P
V
A
Y
G
C
K
V
E
S
I
Zebra Danio
Brachydanio rerio
NP_998562
536
62010
G481
F
K
K
P
R
I
D
G
L
D
E
P
I
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
H416
P
Y
I
D
I
P
L
H
S
L
V
K
L
T
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
I411
Y
G
T
K
V
T
K
I
K
A
N
I
P
A
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.7
99.6
84.6
N.A.
65.5
89.9
N.A.
76.6
61.1
65.5
72.3
N.A.
N.A.
N.A.
47.1
N.A.
Protein Similarity:
100
97.1
99.8
87.6
N.A.
77.8
91.7
N.A.
84.2
77.1
76.7
84.1
N.A.
N.A.
N.A.
62.8
N.A.
P-Site Identity:
100
100
100
13.3
N.A.
0
0
N.A.
6.6
13.3
6.6
40
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
20
33.3
N.A.
26.6
26.6
26.6
60
N.A.
N.A.
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
40.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
9
0
0
17
9
9
9
9
0
0
42
0
% A
% Cys:
0
0
0
9
0
0
0
0
0
17
0
0
0
0
0
% C
% Asp:
0
0
0
9
0
0
17
0
0
17
0
0
0
0
0
% D
% Glu:
0
9
0
0
0
9
0
0
0
25
42
0
17
0
0
% E
% Phe:
17
0
0
0
0
0
0
0
25
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
0
0
9
9
17
0
9
0
0
0
0
% G
% His:
0
0
0
0
0
9
0
9
0
0
0
25
0
0
0
% H
% Ile:
0
0
9
0
9
34
0
9
0
9
0
9
17
9
17
% I
% Lys:
0
50
34
9
9
0
9
0
25
17
9
17
9
0
0
% K
% Leu:
25
9
17
9
0
0
9
0
9
9
0
0
9
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
25
9
0
0
9
0
9
9
9
% N
% Pro:
17
0
9
34
25
9
9
0
0
0
9
17
17
9
17
% P
% Gln:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
42
0
0
0
0
0
9
17
0
9
9
% R
% Ser:
0
0
17
9
9
9
9
25
9
0
0
0
0
17
34
% S
% Thr:
25
9
9
17
0
9
0
17
9
0
0
0
0
9
0
% T
% Val:
9
9
0
0
9
17
0
0
0
0
9
17
25
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
9
0
0
0
0
0
17
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _